Sunday, February 24, 2019

Malaria: Plasmodium parasite overview and Treatment


Malaria is a mosquito borne life threatening disease that are caused by the parasite plasmodium. These are generally caused by bite of Anopheles mosquito which can be transmitted to humans via various ways. This destroys the red blood cells once when the infected mosquito bites the human and the parasite multiply causing infection.

This type of infection can be detected in the early stage itself through some of the symptoms such as fever, chills, prostration, prone position, multiple consciousness, deep breathing in worst cases this can lead to abnormal bleeding, signs of anemia, clinical jaundice and sometimes vital organ dysfunction. These symptoms can be identified on an average of 10 to 11 days.

According to WHO (World Health Organization) a confirmation on a microscopic laboratory testing or a rapid diagnostic test is necessary for the identification and conformation of the disease. These symptoms without treatment may lead to the transmission of the disease to the surrounding population.


ACT (Artemisinin based combination therapy) which is obtained from the plant Artemisia annua is generally recommended by the uncomplicated or initial stage of malaria as it has the ability to reduce plasmodium. In severe cases intravenous artesunate is acting as a parasite clearance where it reduces the risk rate in body. Quinine is the most common drug of choice in the treatment of malaria, but this dosage and injection of this drug varies and should be carefully maintained for the pregnancy patients and cardio patients. Sometimes Quinidine is used as an alternative for quinine. Quinine should be given for a minimum of five days and can be stopped thereafter once the patient is aparasitaemic for two consecutive blood films, taken 24 h apart.

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